Mutagenic Activity of Disinfection By-Products

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Mutagenic activity of disinfection by-products.

Data on raw water quality, disinfection treatment practices, and the resulting mutagenic properties of the treated water were compiled from pilot- and full-scale treatment experiments to evaluate that parameter which might produce variability in the results of a mutagenic study. Analysis of the data and comparison of treatment practices indicated that the measured mutagenic activity is strongly...

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The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration.

Epidemiologic studies of disinfection by-products have traditionally focused on total trihalomethane (TTHM) concentration as a surrogate for maternal exposure during pregnancy. We used birth certificate data on 196,000 infants to examine the effect of third-trimester exposures on various indices of fetal development. We examined the effect of town-average concentrations of TTHM and additional e...

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Mutagenic activity associated with by-products of drinking water disinfection by chlorine, chlorine dioxide, ozone and UV-irradiation.

A retrospective epidemiological study in The Netherlands showed a statistical association between chlorination by-products in drinking water and cancer of the esophagus and stomach for males. A pilot-plant study with alternative disinfectants was carried out with stored water of the Rivers Rhine and Meuse. It was demonstrated that the increase of direct acting mutagens after treatment with chlo...

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Disinfection By-products: A Question of Balance

By all accounts, disinfection of drinking water is one of the major public health triumphs of the 20th century. No human endeavor, however, is without risk; more than 30 years ago it was determined that chlori­ nation of water resulted in formation of disinfection by­products (DBPs). Several of these, such as the trihalomethanes (THMs) and haloacetic acids (HAAs), were subsequently observed to ...

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Reproductive toxicology of disinfection by-products.

The chronic exposure of large segments of the population to disinfected drinking water has necessitated an evaluation of the health effects of the by-products of the chlorination process. This paper reviews the available information concerning the reproductive consequences associated with exposure to disinfection by-products. Four groups of compounds are discussed: the trihalomethanes, in parti...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1986

ISSN: 0091-6765

DOI: 10.2307/3430384